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	<title>ReadingThinkingAndWriting</title>
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	<link>http://blog.readingthinkingandwriting.com</link>
	<description>Thoughts on matters of relative importance</description>
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		<title>MIT and the Demise of the Viral Infection</title>
		<link>http://blog.readingthinkingandwriting.com/?p=500</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=500#comments</comments>
		<pubDate>Fri, 28 Dec 2012 05:55:52 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Health Science]]></category>
		<category><![CDATA[Immunology]]></category>
		<category><![CDATA[AIDS]]></category>
		<category><![CDATA[DRACO]]></category>
		<category><![CDATA[Flu]]></category>
		<category><![CDATA[HIV]]></category>
		<category><![CDATA[Influenza]]></category>
		<category><![CDATA[MIT]]></category>
		<category><![CDATA[Virus]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=500</guid>
		<description><![CDATA[Scott Tarone Looking for a cure for the common cold? Well, the preliminary testing in mice and human cell cultures is in and it looks like Dr. Rider, along with Scott Wick, Christina Zook, Tara Boettcher, Jennifer Pancoast, and Benjamin Zusman, have done just that; and then some. (Update: Dr. Rider informed me that Jennifer [...]]]></description>
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		<slash:comments>1</slash:comments>
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		<title>Intracellular Caspase-Modulating Chimeric Antigen Receptor</title>
		<link>http://blog.readingthinkingandwriting.com/?p=411</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=411#comments</comments>
		<pubDate>Thu, 29 Mar 2012 17:52:35 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Antibodies]]></category>
		<category><![CDATA[antigen receptors]]></category>
		<category><![CDATA[Cancer]]></category>
		<category><![CDATA[Caspase]]></category>
		<category><![CDATA[Caspase-3]]></category>
		<category><![CDATA[Chimeric Antigen Receptor]]></category>
		<category><![CDATA[Directed Evolution]]></category>
		<category><![CDATA[Immunology]]></category>
		<category><![CDATA[Inteins]]></category>
		<category><![CDATA[mAb]]></category>
		<category><![CDATA[Protein engineering]]></category>
		<category><![CDATA[Targeted Cancer Therapy]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=411</guid>
		<description><![CDATA[&#160; Abstract Published article The Chimeric Antigen Receptor (CAR), first devised by Gross et al in 1989 (1), has proven effective against cancer and holds promise for other therapeutic applications. Landmark work done by Carl June M.D. et al. led to a recent clinical trial in which CD-19 specific-CAR transfected autologous T cells were reinfused [...]]]></description>
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		<slash:comments>0</slash:comments>
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		<title>Directed Evolution: Going From Millions of Years to a Matter of Days</title>
		<link>http://blog.readingthinkingandwriting.com/?p=350</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=350#comments</comments>
		<pubDate>Wed, 07 Dec 2011 03:56:59 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Health Science]]></category>
		<category><![CDATA[Chimeric Proteins]]></category>
		<category><![CDATA[Creating Proteins]]></category>
		<category><![CDATA[Directed Evolution]]></category>
		<category><![CDATA[Evolution]]></category>
		<category><![CDATA[New Proteins]]></category>
		<category><![CDATA[Protein engineering]]></category>
		<category><![CDATA[Protein Modularity]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=350</guid>
		<description><![CDATA[Now imagine the evolution of a new protein function not over millions of years, but rather in just a few days.  A new function emerging not in response to an environmental change challenging life, but rather in response to a functional goal set by a human standing in a lab. This is not the start of a science fiction writer's prophetic tale. This is Directed Evolution, a technique that is now commonly used to enhance existing and even create new proteins in labs all over the world.]]></description>
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		<slash:comments>1</slash:comments>
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		<item>
		<title>Intracellular Caspase-Modulating Chimeric Antigen Receptor</title>
		<link>http://blog.readingthinkingandwriting.com/?p=329</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=329#comments</comments>
		<pubDate>Fri, 11 Nov 2011 02:42:45 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Antibodies]]></category>
		<category><![CDATA[antigen receptors]]></category>
		<category><![CDATA[Cancer]]></category>
		<category><![CDATA[Caspase]]></category>
		<category><![CDATA[Caspase-3]]></category>
		<category><![CDATA[Chimeric Antigen Receptor]]></category>
		<category><![CDATA[Directed Evolution]]></category>
		<category><![CDATA[Immunology]]></category>
		<category><![CDATA[Inteins]]></category>
		<category><![CDATA[mAb]]></category>
		<category><![CDATA[Protein engineering]]></category>
		<category><![CDATA[Targeted Cancer Therapy]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=329</guid>
		<description><![CDATA[I am proposing an approach that differs from the conventional in three ways: (i) directly targeting of tumor specific or associated antigens within the malignant cells with (ii) an antibody based biological agent (iii) containing a constitutively active apoptosis effector that is inhibited or non-functional until the antibody binds its agonist.
 ]]></description>
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		<item>
		<title>The Founders: Death and Taxes</title>
		<link>http://blog.readingthinkingandwriting.com/?p=251</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=251#comments</comments>
		<pubDate>Mon, 01 Aug 2011 12:30:40 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Current]]></category>
		<category><![CDATA[History]]></category>
		<category><![CDATA[Constitution]]></category>
		<category><![CDATA[Continental Congress]]></category>
		<category><![CDATA[Founding]]></category>
		<category><![CDATA[Hamilton]]></category>
		<category><![CDATA[HIstory]]></category>
		<category><![CDATA[Madison]]></category>
		<category><![CDATA[Revolutionary War]]></category>
		<category><![CDATA[Taxes]]></category>
		<category><![CDATA[The Founders]]></category>
		<category><![CDATA[U.S. Host]]></category>
		<category><![CDATA[Washington]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=251</guid>
		<description><![CDATA[The situation near the end of the war echoes eerily today as the states engaged in a war that The Congress was in want of tax revenue to pay for and the debts incurred to do so, both foreign and domestic, threatened to destroy that which so much blood was spilled to gain.]]></description>
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		<title>Chimeric Antigen Receptor: Target erbB2</title>
		<link>http://blog.readingthinkingandwriting.com/?p=221</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=221#comments</comments>
		<pubDate>Sat, 18 Jun 2011 02:18:17 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Adoptive Cell Therapy]]></category>
		<category><![CDATA[Breast Cancer]]></category>
		<category><![CDATA[Cancer]]></category>
		<category><![CDATA[erbB2]]></category>
		<category><![CDATA[HER2]]></category>
		<category><![CDATA[Immunology]]></category>
		<category><![CDATA[Targeted Cancer Therapy]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=221</guid>
		<description><![CDATA[In stark contrast to the years of safe administration and the cancer clearing success stories of late; recently there were two deaths in CAR based clinical trials. The case I'd like to focus on is one in which an on-target/off-tissue event appears to be the cause of death (1). The Cytotoxic T Lymphocyte action was on-target in that its CAR bound to the proper ligand, erbB-2; however it was off-tissue in that the ligand was expressed on normal cells in healthy tissue.
]]></description>
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		<slash:comments>0</slash:comments>
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		<item>
		<title>Adoptive Cell Therapy Part 1: Chimeric Antigen Receptors</title>
		<link>http://blog.readingthinkingandwriting.com/?p=214</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=214#comments</comments>
		<pubDate>Tue, 26 Apr 2011 13:04:01 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Adoptive Cell Therapy]]></category>
		<category><![CDATA[Antibodies]]></category>
		<category><![CDATA[autologous T cells]]></category>
		<category><![CDATA[Cancer]]></category>
		<category><![CDATA[Cancer Treatment]]></category>
		<category><![CDATA[Immune System]]></category>
		<category><![CDATA[Immunoglobulin]]></category>
		<category><![CDATA[T Cells]]></category>
		<category><![CDATA[Targeted Cancer Therapy]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=214</guid>
		<description><![CDATA[Imagine a person with Stage IV Chronic Lymphocytic Leukemia, a cancer of the white blood cells. A scan of his bone marrow shows almost complete replacement of healthy cells with cancerous. The cancer is chemorefractory, meaning it survives every dose even while his normal rapidly dividing cells do not. Now, instead of the normal treatment progression and a poor prognosis, some healthy T cells are extracted from his blood. They are processed, induced to replicate, and then the large resulting colony of cells is infused back into his blood. Thirty days later, a scan reveals his bone marrow to be clear of the cancer and another 6 months later shows the same; a complete resolution to the cancer.]]></description>
		<wfw:commentRss>http://blog.readingthinkingandwriting.com/?feed=rss2&#038;p=214</wfw:commentRss>
		<slash:comments>0</slash:comments>
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		<item>
		<title>Somatic Recombination Part 4: Cutting up your DNA</title>
		<link>http://blog.readingthinkingandwriting.com/?p=157</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=157#comments</comments>
		<pubDate>Sun, 06 Mar 2011 16:06:08 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Immunology]]></category>
		<category><![CDATA[B Cells]]></category>
		<category><![CDATA[Cancer]]></category>
		<category><![CDATA[Hematopoietic]]></category>
		<category><![CDATA[Molecular Biology]]></category>
		<category><![CDATA[Recombinase]]></category>
		<category><![CDATA[Recombination]]></category>
		<category><![CDATA[Stem Cells]]></category>
		<category><![CDATA[T Cells]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=157</guid>
		<description><![CDATA[So you've been told that all the cells in your body contain the same DNA?]]></description>
		<wfw:commentRss>http://blog.readingthinkingandwriting.com/?feed=rss2&#038;p=157</wfw:commentRss>
		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Somatic Recombination Part 3: Odd Genes, Viral Action</title>
		<link>http://blog.readingthinkingandwriting.com/?p=123</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=123#comments</comments>
		<pubDate>Mon, 14 Feb 2011 02:59:04 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Immunology]]></category>
		<category><![CDATA[Adaptive Immunity]]></category>
		<category><![CDATA[Antibodies]]></category>
		<category><![CDATA[Autosomal Recombination]]></category>
		<category><![CDATA[B Cell Receptors]]></category>
		<category><![CDATA[Immune System]]></category>
		<category><![CDATA[Immunity]]></category>
		<category><![CDATA[Immunoglobulins]]></category>
		<category><![CDATA[T Cell Receptors]]></category>
		<category><![CDATA[Transposase]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=123</guid>
		<description><![CDATA[...the mechanism by which a retrovirus integrates its genetic material into the infected cell is very similar to the mechanism by which our B and T cells produce the molecules needed to recognize and defeat bacterial and viral infections.]]></description>
		<wfw:commentRss>http://blog.readingthinkingandwriting.com/?feed=rss2&#038;p=123</wfw:commentRss>
		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Somatic Recombination: Part 2, Transmembrane Receptors</title>
		<link>http://blog.readingthinkingandwriting.com/?p=77</link>
		<comments>http://blog.readingthinkingandwriting.com/?p=77#comments</comments>
		<pubDate>Sat, 08 Jan 2011 03:40:12 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Immunology]]></category>
		<category><![CDATA[Antibodies]]></category>
		<category><![CDATA[bacteria]]></category>
		<category><![CDATA[biology]]></category>
		<category><![CDATA[Genetics]]></category>
		<category><![CDATA[microbiology]]></category>
		<category><![CDATA[neutrophil chases bacterium]]></category>
		<category><![CDATA[Receptors]]></category>
		<category><![CDATA[transmembrane receptors]]></category>

		<guid isPermaLink="false">http://blog.readingthinkingandwriting.com/?p=77</guid>
		<description><![CDATA[ Errors in intracellular signaling have been shown to play a role in cancer and autoimmune disorders such as diabetes as well as a variety of other diseases.]]></description>
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